Description
Product Characteristics:
Aliases: BC046431 antibody, Gm878 antibody, KIAA1556 antibody, KIAA1639 antibody, OBSCN antibody, OBSCN_HUMAN antibody, Obscurin antibody, Obscurin-MLCK antibody, Obscurin-myosin light chain kinase antibody, Obscurin-RhoGEF antibody, OTTMUSG00000005786 antibody, UNC89 antibody
Target Information: The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]